June 26, 2025

So, a quick story…

I was at the gym recently doing my thing when I looked over and noticed this guy—let’s call him Mike. Solid dude, in his late 50s. Not flashy, just focused. But here’s the thing…

He was moving the same weight I was.

Now, for context, I’m 47, 235 lbs (after losing over 50 pounds, thanks to GLP-1 peptides), thick and athletic, and I train hard. So seeing a guy 10 years older going set-for-set with me got my attention.

I finally asked him what he was doing differently. No hesitation—he goes:

“SLU‑PP‑332. It’s not a stim or a steroid. It makes your body start acting like it’s been doing endurance training… even when it hasn’t.”

At first I was intrigued. But then I heard the term ERR “Estrogen-Related Receptors” and immediately thought:

“Wait—estrogen?! Nope. I’m out.”

But I’m glad I hit pause and dug into it.

First Off: ERRs Have Nothing to Do with Estrogen. Seriously.

Yeah, the name is terrible. “Estrogen-Related Receptors” sounds like something that’ll tank your T levels and make you emotional. But here’s the truth:

ERRs aren’t activated by estrogen. They were only named that way because they look similar in structure to estrogen receptors. But functionally? They do something completely different.

ERRs are more like metabolic master switches—they control how efficiently your body creates energy, burns fat, and builds mitochondria. They’re found in high-energy tissues like:

• Muscles

• Liver

• Heart

• Brain

The subtype that SLU‑PP‑332 activates—ERRα—is heavily involved in fat oxidation, mitochondrial output, and endurance capacity. This isn’t about hormones—it’s about performance at the cellular level.

🧬 So What Exactly Is SLU‑PP‑332?

It’s a synthetic molecule developed to activate ERRα, mimicking many of the effects your body would normally get from long-term endurance training.

In studies on mice, researchers found that SLU‑PP‑332:

• Increased fat oxidation, even while resting

• Boosted endurance (up to 50% longer run time)

• Reduced fat mass

• Dropped fasting insulin and blood sugar

• Improved mitochondrial function in multiple organs

The wild part? These changes happened without exercise and without any change in food intake. The metabolism just… shifted.

That’s why this molecule is often referred to as an exercise mimetic—it triggers many of the benefits of training, without the physical act of doing it.

🤔 “But Isn’t This Like NAD+ or MOTS‑c?”

That was my first question too—because I’ve been using NAD+ and MOTS-c in my personal protocol for a while now for the improved mitochondrial function resulting in more energy that translates to better workouts… 

Here’s how they compare:

So NAD+ and MOTS-c support the system from inside—SLU‑PP‑332 is more like flipping the master switch that tells your body: “We train. We go hard. Burn fat. Build engines.”

They’re different, but complementary. And I’m seriously excited to stack them.

💊 One Concern I Had: “Why Is It in Pill Form?”

Here’s where I hit a speed bump… all I could find were capsule forms.

And that made me pause because I know how peptides usually break down in your gut if taken orally. Stomach acid wrecks them before they can do anything useful.

But after digging in further, I learned that SLU‑PP‑332 is not a peptide at all—it’s a synthetic small molecule. That means it’s built to survive the digestive process and be absorbed intact.

This is a huge difference. Small molecules are more like traditional pharmaceuticals—they can often be:

• Taken orally

• Absorbed systemically

• Delivered in capsule or tablet form

So yes, the capsule form makes sense in this case, and I’m no longer worried about oral delivery. That said, bioavailability still depends on the formulation, so we’ll see how effective it feels when I run it in real time.

🔥 But Wait—There’s More! (BAM15)

In my research I kept seeing SLU‑PP‑332 paired with something called BAM15. What’s that?

BAM15 is a mitochondrial uncoupler—it makes your mitochondria work harder, burning more fuel (especially fat), even at rest.
It’s like putting your metabolism on high idle—more energy in, more heat or fuel burned out.

Studies show BAM15:

• Increases fat burning without hunger suppression (source)

• Improves insulin sensitivity and liver health (source)

• Reverses obesity in mice without affecting food intake or body temperature (source)

So why combine it with SLU‑PP‑332?

Because SLU builds more and better mitochondria.
BAM15 makes those mitochondria burn harder.

It’s like upgrading your engine (SLU), then flooring the gas (BAM15).
Two-pronged metabolic attack.

This stack—SLU + BAM15—is all over advanced research protocols focused on fat loss, metabolic health, and endurance training mimetics.

🧪 Research Use Only

Just a reminder: SLU‑PP‑332 and BAM15 are research chemicals, not approved for human use. Most available forms are for lab-grade, preclinical work only.

But as a guy always seeking performance optimization and cellular health? I’m all in on watching this space closely.

Final Thoughts: Not a Shortcut, But a Smart Amplifier

I train hard, eat clean, and recover well. But I’m also a biohacker at heart—always looking for tools that complement what I’m doing.

If SLU‑PP‑332 builds more mitochondria and BAM15 ramps up their activity—without touching hormones or relying on stimulants—that’s exciting.

This isn’t a cheat. It’s a deliberate amplifier.

My SLU + BAM15 arrives soon. I’ll be stacking it with NAD+ and MOTS-c, documenting the process, and sharing my thoughts… I’ve been waiting a long time for this and I can’t wait to get started!